I never got the appeal of Malcolm in the Middle. Sure, it gave Frankie Muniz a good, even great, start in some people's minds. It was a fairly good show, but seriously. The mom was a complete bitch, and the dad was a pussy. The brothers had their moments, but overall, I didn't find it that awesome.
Curb Your Enthusiasm, however infrequent that I watch, (I don't have HBO) it is still a great show. Larry David is one of the funniest bastards ever, and it is pretty much a fictionalized version of his life, which is always great. Not to mention, an outtake from the show helped a guy stay away from jail, and even Capital Punishment. Did Malcolm in the Middle do that? I think not.